StressCovidV1, France, Analysis, bibRecord, 000210

Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS

Identifieur interne : 000210 ( France/Analysis ); précédent : 000209; suivant : 000211

Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS

Auteurs : Charles-Edauard Luyt [France] ; Alain Combes [France] ; Marie-Hélène Becquemin [France] ; Catherine Beigelman-Aubry [France] ; Stéphane Hatem [France] ; Anne-Laure Brun [France] ; Nizar Zraik [France] ; Fabrice Carrat [France] ; Philippe A. Grenier [France] ; Jean-Chilstophe M. Richard [France] ; Alain Mercat [France] ; Laurent Brochard [Suisse] ; Christian Brun-Buisson [France] ; Jean Chastre [France]

Source :

Chest : (American College of Chest Physicians) [ 0012-3692 ] ; 2012.

RBID : Pascal:12-0371302

Descripteurs français

Pascal (Inist)
- Long terme, Pronostic, Grave, Anesthésie, Appareil circulatoire, Cardiologie, Forme grave, Grippe H1N1, Virus grippal A(H1N1).

English descriptors

KwdEn :
- Anesthesia, Cardiology, Circulatory system, H1N1 influenza, Influenza A (H1N1), Long term, Prognosis, Severe.

Abstract

Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m²) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.

Affiliations:

France, Suisse
Haute-Normandie, Pays de la Loire, Région Normandie, Île-de-France
Angers, Créteil, Paris, Rouen

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000062
to stream PascalFrancis, to step Curation: 000188
to stream PascalFrancis, to step Checkpoint: 000036
to stream Main, to step Merge: 001478
to stream Main, to step Curation: 001476
to stream Main, to step Exploration: 001476
to stream France, to step Extraction: 000210

Links to Exploration step

Pascal:12-0371302

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS</title>
<author><name sortKey="Luyt, Charles Edauard" sort="Luyt, Charles Edauard" uniqKey="Luyt C" first="Charles-Edauard" last="Luyt">Charles-Edauard Luyt</name>
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</author>
<author><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Intensive Care Unit Hôpitaux Universitaires de Genève</s1>
<s2>Genève</s2>
<s3>CHE</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Intensive Care Unit Hôpitaux Universitaires de Genève</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brun Buisson, Christian" sort="Brun Buisson, Christian" uniqKey="Brun Buisson C" first="Christian" last="Brun-Buisson">Christian Brun-Buisson</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Service de Réanimation Médicale Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Reanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique- Hôpitaux de Paris et Université Paris 6-Pierre-et-Marie-Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Chest : (American College of Chest Physicians)</title>
<title level="j" type="abbreviated">Chest : (Amer. Coll. Chest Phys.)</title>
<idno type="ISSN">0012-3692</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Chest : (American College of Chest Physicians)</title>
<title level="j" type="abbreviated">Chest : (Amer. Coll. Chest Phys.)</title>
<idno type="ISSN">0012-3692</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia</term>
<term>Cardiology</term>
<term>Circulatory system</term>
<term>H1N1 influenza</term>
<term>Influenza A (H1N1)</term>
<term>Long term</term>
<term>Prognosis</term>
<term>Severe</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Long terme</term>
<term>Pronostic</term>
<term>Grave</term>
<term>Anesthésie</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Forme grave</term>
<term>Grippe H1N1</term>
<term>Virus grippal A(H1N1)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate. Methods: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m<sup>2</sup>
) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated. Results: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for post-traumatic stress disorder (41% and 44%). Conclusions: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Suisse</li>
</country>
<region><li>Haute-Normandie</li>
<li>Pays de la Loire</li>
<li>Région Normandie</li>
<li>Île-de-France</li>
</region>
<settlement><li>Angers</li>
<li>Créteil</li>
<li>Paris</li>
<li>Rouen</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Luyt, Charles Edauard" sort="Luyt, Charles Edauard" uniqKey="Luyt C" first="Charles-Edauard" last="Luyt">Charles-Edauard Luyt</name>
</region>
<name sortKey="Becquemin, Marie Helene" sort="Becquemin, Marie Helene" uniqKey="Becquemin M" first="Marie-Hélène" last="Becquemin">Marie-Hélène Becquemin</name>
<name sortKey="Beigelman Aubry, Catherine" sort="Beigelman Aubry, Catherine" uniqKey="Beigelman Aubry C" first="Catherine" last="Beigelman-Aubry">Catherine Beigelman-Aubry</name>
<name sortKey="Brun Buisson, Christian" sort="Brun Buisson, Christian" uniqKey="Brun Buisson C" first="Christian" last="Brun-Buisson">Christian Brun-Buisson</name>
<name sortKey="Brun, Anne Laure" sort="Brun, Anne Laure" uniqKey="Brun A" first="Anne-Laure" last="Brun">Anne-Laure Brun</name>
<name sortKey="Carrat, Fabrice" sort="Carrat, Fabrice" uniqKey="Carrat F" first="Fabrice" last="Carrat">Fabrice Carrat</name>
<name sortKey="Chastre, Jean" sort="Chastre, Jean" uniqKey="Chastre J" first="Jean" last="Chastre">Jean Chastre</name>
<name sortKey="Combes, Alain" sort="Combes, Alain" uniqKey="Combes A" first="Alain" last="Combes">Alain Combes</name>
<name sortKey="Grenier, Philippe A" sort="Grenier, Philippe A" uniqKey="Grenier P" first="Philippe A." last="Grenier">Philippe A. Grenier</name>
<name sortKey="Hatem, Stephane" sort="Hatem, Stephane" uniqKey="Hatem S" first="Stéphane" last="Hatem">Stéphane Hatem</name>
<name sortKey="Mercat, Alain" sort="Mercat, Alain" uniqKey="Mercat A" first="Alain" last="Mercat">Alain Mercat</name>
<name sortKey="Richard, Jean Chilstophe M" sort="Richard, Jean Chilstophe M" uniqKey="Richard J" first="Jean-Chilstophe M." last="Richard">Jean-Chilstophe M. Richard</name>
<name sortKey="Zraik, Nizar" sort="Zraik, Nizar" uniqKey="Zraik N" first="Nizar" last="Zraik">Nizar Zraik</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS

Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS

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